Genotyping for Progress in Hemophilia


genetics 101

  • you

    genetics is the study of heredity — the inherited characteristics that make each of us unique

  • cells

    Our bodies are made up of millions and millions of cells that act as the fundamental structure of all living organisms.

  • DNA

    Deep within each cell is a ladder-shaped molecule known as DNA.

  • gene

    Certain sections of DNA form genes. Genes are blueprints for making proteins, each of which serves a particular function in the body.

    DNA and genes are composed of long series of individual units (or nucleic acids) – Adenine (A), Cytosine (C), Guanine (G) and Thymine (T).

  • sequence

    The specific order or sequence of DNA units is the basis for the genetic information unique to you.

    Any permanent change to the DNA sequence is called a variant. These changes can be inherited from your parents or caused by environmental factors during your lifetime.

    Because a variant is a change to a gene, it alters the body's protein-making instructions and can impact critical processes within the body.

  • A genotype is a category of gene mutation that causes a specific condition or disorder.

    Learn more about how, in hemophilia, genotypes can be determined by analyzing the DNA sequence of the gene in question – factor VIII gene for hemophilia A and factor IX gene for hemophilia B.